![]() ![]() Broad spectrum antiepileptic drugs (valproate, levetiracetam, lamotrigine, topiramate) alone, but more commonly in combination, are the main prophylactic treatment.Īlthough absences are considered a paradigm of primarily generalized seizures, they may occasionally be of focal onset (focal onset generalized absence seizures), usually arising from focal, mainly frontal lobe, brain pathology ( 09 16 45 08 10). ![]() Prognosis is variable depending on the underlying cause.EEG and MRI are the main modes of investigations.Approximately one-third of patients with Lennox-Gastaut syndrome manifest with atypical absence seizures due to secondary bilateral synchrony-that is bilateral and synchronous 2 to 4 Hz EEG discharges generated by a unilateral cortical focus.The most classic focal onset generalized absence seizures are those manifested in patients with focal structural, mainly frontal, brain abnormalities.Focal onset generalized absence seizures may manifest either as typical (with > 2.5 Hz spike-wave discharges) or atypical (with 2.5 Hz spike-wave discharges) or atypical (with < 2.5 Hz spike-wave discharges) absence seizures. Although absences are considered a paradigm of primarily generalized seizures, they may occasionally be of focal onset (focal onset generalized absence seizures), usually arising from focal brain pathology. ![]()
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